Friends in happy San Luis Obispo are about to lose their jobs so they leap into action; a funny series of selfish lurches which lead to betrayal, an accident, several attempts at pregnancy, and some pithy California soul-searching.

An unmonitored clandestine research project suffers a "technical malfunction" and each of the isolated volunteers must devise an escape plan or face certain death.

Nick must put aside the bong and rally his crew of stoner friends when their new hipster roommate transforms into a murderous werewolf.