Struggling with new parenthood and stalling careers, Kallia and Ram's lives are thrown into chaos when Kallia's blind mother goes on a mission to exorcize the family from the evil eye.

After hitting dead ends in life, Jyothi, an Indian housewife, and Sophie, a stoner musician, find themselves on the run from the law, together on a wild, surreal American road trip from Durham, North Carolina to Montreal, Canada.