Saints and Sinners is an American drama series that aired on NBC during the 1962-63 television season. The program stars Nick Adams as newspaper reporter Nick Alexander. Saints and Sinners was created by Adrian Spies, who worked as a journalist before becoming a screenwriter.

Trapped on a remote island by a hurricane, a group discover a doctor has been experimenting on creating half sized humans. Unfortunately, his experiments have also created giant shrews, who when they have run out of small animals to eat, turn on the humans.

A small town in Texas finds itself under attack from a hungry, fifty-foot-long gila monster. No longer content to forage in the desert, the giant lizard begins chomping on motorists and train passengers before descending upon the town itself. Only Chase Winstead, a quick-thinking mechanic, can save the town from being wiped out.

The naive cowboy Tod Lohman accidentally kills the son of the powerful land baron Hunter Boyd. Tod runs for his life, pursued by the dead man's vengeful brothers. Tod shelters on the ranch of Amos Bradley and he falls in love with his daughter Juanita. However, Tod is concerned that he'll eventually have to leave when his pursuers catch up with him.

A pathologist experiments with a deaf-mute woman who is unable to scream to prove that humans die of fright due to an organism he names The Tingler that lives within each person on the spinal cord and is suppressed only when people scream when scared.

Sharpshooter Calamity Jane takes it upon herself to recruit a famous actress and bring her back to the local saloon, but jealousy soon gets in the way.

After learning the finer points of carrier aviation in the 1920s, career officer Jonathan Scott and his pals spend the next two decades promoting the superiority of naval air power. But military and political "red tape" continually frustrate their efforts, prompting Scott to even consider leaving the Navy for a more lucrative civilian job. Then the world enters a second World War and Scott finally...

Sharpshooter Calamity Jane takes it upon herself to recruit a famous actress and bring her back to the local saloon, but jealousy soon gets in the way.

Three struggling theatrical performers meet a famous songwriter who is trying to convince a wealthy oilman to finance a musical he is scripting, promising them stardom if it comes to fruition.

Inspired by Churchill's Dunkirk speech, brash, undisciplined Canadian bush pilot Brian MacLean and three friends enlist in the RCAF.

A Union soldier returns to his western home at the end of the Civil War and finds himself caught in the middle of a land war between his greedy half-brother and a wagon train of Confederate homesteaders.

Conceited singer Garry Mitchell refuses to renew his radio contract, so agent Doug Blake decides to find a new personality to replace him. In New York, he finds Martha Gibson, a single mother with a great voice. He arranges for her to move to Hollywood, but then has a problem trying to sell her to the show's sponsor. Doug tries every trick he can think of to make Martha a star, and as the two work...